abstract：:Retinitis pigmentosa is a blinding disease in which unknown mechanisms cause the degeneration of retinal photoreceptors. The retinal degeneration (rd1) mouse is a relevant model for this condition, since it carries a mutation also found in some forms of retinitis pigmentosa. To understand the degenerative process in t...

journal_title：Cell and tissue research

authors： Johnson LE,van Veen T,Ekström PA

更新日期：2005-05-01 00:00:00

abstract：:The expression of nicotinic acetylcholine receptors (nAChR) in fetal lung suggests maternal smoking during pregnancy effects newborn lung structure and function by the direct interaction of nicotine with nAChR in the developing lung. The recent identification of the lynx1 nAChR modulator protein in nicotinic neurons i...

journal_title：Cell and tissue research

authors： Sekhon HS,Song P,Jia Y,Lindstrom J,Spindel ER

更新日期：2005-05-01 00:00:00

abstract：:DBA/2J (D2) mice develop a form of progressive pigmentary glaucoma with increasing age. We have compared retinal cell populations of D2 mice with those in control C57BL/6J mice to provide information on retinal histopathology in the D2 mouse. The D2 mouse retina is characterized by a reduction in retinal thickness cau...

journal_title：Cell and tissue research

authors： Moon JI,Kim IB,Gwon JS,Park MH,Kang TH,Lim EJ,Choi KR,Chun MH

更新日期：2005-04-01 00:00:00

abstract：:The gene Ag-Aper14 encodes a novel peritrophic matrix (or peritrophic membrane; PM) protein in the mosquito Anopheles gambiae. The Ag-Aper14 protein is merely 89 amino acids long and has a single putative chitin-binding domain. Prior to blood feeding, the Ag-Aper14 protein is stored in secretory vesicles next to the e...

journal_title：Cell and tissue research

authors： Devenport M,Fujioka H,Donnelly-Doman M,Shen Z,Jacobs-Lorena M

更新日期：2005-04-01 00:00:00

abstract：:Although the function and effects of many growth factors and extracellular matrix (ECM) molecules have been described for several periodontal tissues in vivo and in vitro, the molecular interactions involved in the communication between cells of the periodontal ligament and the alveolar bone are poorly understood. To ...

journal_title：Cell and tissue research

authors： Winter S,Kohl A,Huppertz A,Herold-Mende C,Wiest T,Komposch G,Tomakidi P

更新日期：2005-03-01 00:00:00

abstract：:The spatial localisation of insulin-like growth-factor-binding protein-2 (IGFBP-2) and its mRNA was investigated during larval and post-larval developmental stages of the gilthead seabream ( Sparus aurata) by immunohistochemistry and in situ hybridisation with specific antisera and riboprobes. During larval developmen...

journal_title：Cell and tissue research

authors： Radaelli G,Patruno M,Rowlerson A,Maccatrozzo L,Funkenstein B

更新日期：2005-01-01 00:00:00

abstract：:Purinoceptor subtypes were localised to various tissue types present within the nasal cavity of the rat, using immunohistochemical methods. P2X3 receptor immunoreactivity was localised in the primary olfactory neurones located both in the olfactory epithelium and vomeronasal organs (VNO) and also on subepithelial nerv...

journal_title：Cell and tissue research

authors： Gayle S,Burnstock G

更新日期：2005-01-01 00:00:00

abstract：:We have analyzed the distribution of neural crest-derived precursors and the expression of catecholaminergic and neuronal markers in developing adrenal tissue of chick embryos. Undifferentiated neural crest cells are found in presumptive adrenal regions from embryonic day 3 (E3) onward. An increasing proportion of cel...

journal_title：Cell and tissue research

authors： Ernsberger U,Esposito L,Partimo S,Huber K,Franke A,Bixby JL,Kalcheim C,Unsicker K

更新日期：2005-01-01 00:00:00

abstract：:Vasodilator-stimulated phosphoprotein (VASP) and mammalian-enabled protein (MENA) share similar cellular localisation and functions (signal transduction pathways, regulation of actin cytoskeleton dynamics). Functional substitution and compensation among Ena/VASP proteins have been proposed as the reason for the absenc...

journal_title：Cell and tissue research

authors： Schick B,Praetorius M,Eigenthaler M,Jung V,Müller M,Walter U,Knipper M

更新日期：2004-12-01 00:00:00

abstract：:Colitis is associated with alterations in electrolyte and water transport. These changes give rise to some of the symptoms experienced by patients with colitis. Alterations in fluid flux may also contribute to increased susceptibility to mucosal injury. Recently, endogenous water channel proteins (aquaporins; AQPs), h...

journal_title：Cell and tissue research

authors： Hardin JA,Wallace LE,Wong JF,O'Loughlin EV,Urbanski SJ,Gall DG,MacNaughton WK,Beck PL

更新日期：2004-11-01 00:00:00

abstract：:The diabetes (db/db) mutation (leptin-receptor defect) induces a hyperglycemic-hyperinsulinemic endometabolic environment that promotes hypercytolipidemic ovarian involution in C57BL/KsJ mice, resulting in reproductive sterility and eventual organoatrophy. The effectiveness of low-dose (1.0 microg/sc/3.5 day intervals...

journal_title：Cell and tissue research

authors： Garris DR

更新日期：2004-11-01 00:00:00

abstract：:Neural stem cells (NSCs) are a subtype of tissue-specific progenitor cells capable of extended self-renewal and the ability to generate all major cell types of nervous tissue, such as neurons, astroglia and oligodendroglial cells. Recent studies suggest that salient patterning in anterior-posterior and dorsal-ventral ...

journal_title：Cell and tissue research

authors： Storch A,Sabolek M,Milosevic J,Schwarz SC,Schwarz J

更新日期：2004-10-01 00:00:00

abstract：:The etiologic basis of Parkinson's disease (PD), the second most common age-related neurodegenerative disorder, is unknown. Recent epidemiological and experimental studies indicate that exposure to environmental agents, including a number of agricultural chemicals, may contribute to the pathogenesis of this disorder. ...

journal_title：Cell and tissue research

authors： Uversky VN

更新日期：2004-10-01 00:00:00

abstract：:Loss of serotonergic and dopaminergic neurons may have serious implications for normal brain function. Drosophila models of neurodegenerative diseases utilize the short life-span and simple anatomy of the fly to characterize the molecular and genetic processes characteristic of each dysfunctional state. In fly embryon...

journal_title：Cell and tissue research

authors： Sykes PA,Norman HS,Condron BG

更新日期：2004-09-01 00:00:00

abstract：:A monoclonal antibody (Mab) developed against a partially purified bursal protein extract was found to bind specifically to a single cell type in the cortico-medullary border region of the chicken bursa of Fabricius. These cells were microscopically similar to the bursal secretory dendritic-like cells. A product with ...

journal_title：Cell and tissue research

authors： Moore RW,Hargis BM,Porter TE,Caldwell DY,Oubre CM,Vandesande F,Berghman LR

更新日期：2004-09-01 00:00:00

abstract：:In an organ culture system under a three-dimensional microenvironment that provides the conditions needed for odontoblast differentiation, a row of odontoblasts can be induced (Kikuchi et al. 1996, 2001). Therefore, in a newly designed three-dimensional cell culture system that fulfils the conditions necessary for odo...

journal_title：Cell and tissue research

authors： Kikuchi H,Suzuki K,Sakai N,Yamada S

更新日期：2004-08-01 00:00:00

abstract：:The ultrastructural localization of ryanodine receptors (RyR) in sinus endothelial cells of the rat spleen was examined by confocal laser scanning and electron microscopy by using isoform-specific antibodies to each of the RyR isoforms. Immunofluorescence microscopy of tissue cryosections revealed RyR3 to be localized...

journal_title：Cell and tissue research

authors： Uehara K,Onoue H,Jeyakumar LH,Fleischer S,Uehara A

更新日期：2004-08-01 00:00:00

abstract：:The use of porcine hepatocytes in xenotransplantation, bioartificial liver support or pharmacological approaches demands serum-free cryopreservation protocols yielding high quality, viable, functional hepatocytes. Here, primary porcine hepatocytes were frozen without serum in liquid nitrogen by the use of a computer-a...

journal_title：Cell and tissue research

authors： Müller P,Aurich H,Wenkel R,Schäffner I,Wolff I,Walldorf J,Fleig WE,Christ B

更新日期：2004-07-01 00:00:00

abstract：:The purpose of this study was to determine the cellular distribution and degradation in rat liver following intravenous injection of superparamagnetic iron oxide nanoparticles used for magnetic resonance imaging (NC100150 Injection). Relaxometric and spectrophotometric methods were used to determine the concentration ...

journal_title：Cell and tissue research

authors： Briley-Saebo K,Bjørnerud A,Grant D,Ahlstrom H,Berg T,Kindberg GM

更新日期：2004-06-01 00:00:00

abstract：:We have recently identified a tachykinin-related peptide (AmTRP) from the mushroom bodies (MBs) of the brain of the honeybee Apis mellifera L. by using direct matrix-assisted laser desorption/ionization with time-of-flight mass spectometry and have isolated its cDNA. Here, we have examined prepro-AmTRP gene expression...

journal_title：Cell and tissue research

authors： Takeuchi H,Yasuda A,Yasuda-Kamatani Y,Sawata M,Matsuo Y,Kato A,Tsujimoto A,Nakajima T,Kubo T

更新日期：2004-05-01 00:00:00

abstract：:Studies with environmental levels of various metals typically focus on observable neurological symptoms in newborns and adults. Use of the C2C12 skeletal muscle cell line as a developmental model enabled us to test whether environmental insults prevented myotube formation or the assembly of the postsynaptic component ...

journal_title：Cell and tissue research

authors： Miller TJ,Grow WA

更新日期：2004-05-01 00:00:00

abstract：:Within seminiferous tubules, Sertoli cells form three types of actin-filament-containing cell junctions, viz., tight junctions, ectoplasmic specializations, and tubulobulbar complexes. These Sertoli cell junctions are involved in the formation of the blood-testis barrier, germ cell translocation, and the release of sp...

journal_title：Cell and tissue research

authors： Zhu Q,Emanuele NV,Van Thiel DH

更新日期：2004-05-01 00:00:00

abstract：:During metamorphosis, the frog intestine goes through a dramatic shortening with extensive apoptosis and regeneration in the epithelial layer and connective tissue. Our aim was to study changes in the enteric nervous system represented by one inhibitory (vasoactive intestinal polypeptide; VIP) and one excitatory (subs...

journal_title：Cell and tissue research

authors： Sundqvist M,Holmgren S

更新日期：2004-04-01 00:00:00

abstract：:The H-Tx rat has fetal-onset hydrocephalus associated with closure of the cerebral aqueduct and a reduction in the secretory cells of the subcommissural organ (SCO), a circumventricular organ situated in the dorsal wall of the cerebral aqueduct. The objective of this study was to determine the role of the SCO in hydro...

journal_title：Cell and tissue research

authors： Somera KC,Jones HC

更新日期：2004-03-01 00:00:00

abstract：:During pregnancy, the calcium (Ca(2+)) transport machinery of the placenta is solely responsible for the nutrient supply to the developing fetus, where active Ca(2+) transport occurs from the mother to the fetus. As part of a larger study to determine the role of Ca(2+) in placental transport in vivo, we questioned wh...

journal_title：Cell and tissue research

authors： Belkacemi L,Gariépy G,Mounier C,Simoneau L,Lafond J

更新日期：2004-01-01 00:00:00

abstract：:Dendritic cells are migratory cells. Before they extravasate from the circulation into the skin across capillary blood vessel walls, they have to interact with endothelial cells. Using a fluorimetric adhesion assay, we have recently shown that CD34(+)-derived dendritic cell precursors are able to bind to resting and s...

journal_title：Cell and tissue research

authors： Van Nguyen A,Kirchmair M,Fürhapter C,Romani N,Sepp N

更新日期：2004-01-01 00:00:00

abstract：:The expression patterns of three microtubule-associated proteins (MAP1A, MAP1B, and MAP2A&B) were investigated in the developing optic tectum. Expression of MAP1B and middle-molecular-weight peptide of neurofilament (NF-M) was first observed in the same mesencephalic cells on day 3 of incubation, indicating that neuro...

journal_title：Cell and tissue research

authors： Yasuda Y,Fujita S

更新日期：2003-12-01 00:00:00

abstract：:Purinergic P2X receptors associated with the parasympathetic nerves supplying human bladder smooth muscle (detrusor) are implicated in control of detrusor contractility. The relative abundance of all seven subtypes colocalised with synaptic vesicles on parasympathetic nerves was examined in specimens from normal adult...

journal_title：Cell and tissue research

authors： Ray FR,Moore KH,Hansen MA,Barden JA

更新日期：2003-12-01 00:00:00

abstract：:The mechanism of cell death which occurs during Chagas' cardiopathy is disputed. To address this issue we analyzed the molecular pathways implicated in the death of cardiomyocytes during T. cruzi invasion and found that they undergo apoptosis during both in vitro and in vivo infections. However, the death rates and on...

journal_title：Cell and tissue research

authors： de Souza EM,Araújo-Jorge TC,Bailly C,Lansiaux A,Batista MM,Oliveira GM,Soeiro MN

更新日期：2003-11-01 00:00:00

abstract：:This review focuses on the signaling system involving the Angiopoietin1/Tie2 receptor, which appears to be involved in the secondary stages of blood vessel formation. Although this system is crucial for blood and lymphatic vessel formation, identifying its precise role in embryonic and adult vascular biology has been ...

journal_title：Cell and tissue research

authors： Thurston G

更新日期：2003-10-01 00:00:00

abstract：:The cardiovascular system is the first functional organ in the vertebrate embryo, and many organs start to develop adjacent to cells of the cardiovascular system. Endothelial cells (EC) form the inner cell lining of blood vessels and represent the major cell type that interacts with developing organs. On the one hand,...

journal_title：Cell and tissue research

authors： Nikolova G,Lammert E

更新日期：2003-10-01 00:00:00

abstract：:Accumulating evidence suggests that the sympathetic nervous system modulates inflammatory responses and bone remodeling. We have studied the effects of sympathectomy and orthodontic tooth movement (OTM) on root resorption, immunocompetent cell recruitment, neuropeptide, neurokinin-1 receptor (NK1-R), and interleukin 6...

journal_title：Cell and tissue research

authors： Haug SR,Brudvik P,Fristad I,Heyeraas KJ

更新日期：2003-08-01 00:00:00

abstract：:Research in mammals has established the existence of a neuronal network that lies within the hypothalamus and that regulates energy homeostasis. However, it is unknown whether this system has been evolutionarily conserved. The objective of the present study was therefore to examine the influence of the agouti-related ...

journal_title：Cell and tissue research

authors： Phillips-Singh D,Li Q,Takeuchi S,Ohkubo T,Sharp PJ,Boswell T

更新日期：2003-08-01 00:00:00

abstract：:We have previously shown that immunoneutralization of transforming growth factor-beta (TGF-beta) in the chick embryo significantly reduces programmed cell death (PCD) in peripheral neurons, spinal cord, and retina. In order to validate these results we have begun to analyze PCD in mice with targeted ablations of the T...

journal_title：Cell and tissue research

authors： Dünker N,Krieglstein K

更新日期：2003-07-01 00:00:00

abstract：:The intestine, which is exposed to nutrition and to food-derived antigens and microbes including viruses and bacteria, might be an important site for the immune response. Crucial structural and functional differences exist between the small and large intestine, regional differences even having been demonstrated within...

journal_title：Cell and tissue research

authors： Tamura A,Soga H,Yaguchi K,Yamagishi M,Toyota T,Sato J,Oka Y,Itoh T

更新日期：2003-07-01 00:00:00

abstract：:The iron carrier protein transferrin plays a prominent antioxidant and anti-bacterial role in the lower respiratory tract and is present at elevated concentrations in lung epithelial lining fluid relative to plasma. The level of transferrin receptor synthesis in primary cultures of rat alveolar epithelial cells (AECs)...

journal_title：Cell and tissue research

authors： Widera A,Beloussow K,Kim KJ,Crandall ED,Shen WC

更新日期：2003-06-01 00:00:00

abstract：:Colonies of the ascidian Botryllus schlosseri undergo recurrent generation changes in which adult zooids are gradually resorbed and replaced by new blastogenic generations. During these periods, known as take-over phases, programmed cell death, which, on the basis of morphological analysis is ascribed to apoptosis, oc...

journal_title：Cell and tissue research

authors： Cima F,Basso G,Ballarin L

更新日期：2003-06-01 00:00:00

abstract：:The distribution of P2X(2) purine receptor subunit immunoreactivity has been investigated in the mouse gastrointestinal tract. Immunoreactivity occurred in intraganglionic laminar endings (IGLEs) associated with myenteric ganglia throughout the gastrointestinal tract. In the esophagus, IGLEs supplied every myenteric g...

journal_title：Cell and tissue research

authors： Castelucci P,Robbins HL,Furness JB

更新日期：2003-05-01 00:00:00

abstract：:Modifications of hepatocyte cell surface were determined after single i.v. injection to rats of Pb(NO(3))(2) (known to induce liver hyperplasia followed by apoptosis) or GdCl(3) (known to induce proliferation of parenchymal cells and Kupffer cell depletion) or administration of GdCl(3) 24 h before Pb(NO(3))(2) injecti...

journal_title：Cell and tissue research

authors： Pagliara P,Chionna A,Carlà EC,Caforio S,Dini L

更新日期：2003-04-01 00:00:00

abstract：:NdWFamide is an Aplysia cardioexcitatory tri-peptide containing D-tryptophan. To investigate the roles of this peptide, we examined the immunohistochemical distribution of NdWFamide-positive neurons in Aplysia tissues. All the ganglia of the central nervous system (CNS) contained NdWFamide-positive neurons. In particu...

journal_title：Cell and tissue research

authors： Morishita F,Nakanishi Y,Sasaki K,Kanemaru K,Furukawa Y,Matsushima O

更新日期：2003-04-01 00:00:00